Making use of single-molecule optical and AFM imaging and drive-spectroscopy tactics, we seek to unravel the mechanistic aspects of the framework and dynamics of chromosomes. Our exploration passions incorporate:

You frequently get entangled in conversations about science and faith. You may have also composed several textbooks on the topic. Don’t you imagine that sooner or later We're going to know every little thing and that God’s position will probably be about?

‘It had been just a make a difference of buying up a e book on cell biology and starting to examine. I'd come from a environment of extremely-substantial vacuums, cryostats and quantum phenomena, and now I used to be Functioning at space temperature with molecular biology kits.

Non-equilibrium folding of personal DNA molecules recaptured as much as one thousand situations in the solid point out nanopore

That may be a desire of mine and we set to work having a delectable dose of naivety. This is something that will most likely produce magnificent brings about the extended phrase, but that does not matter. You should not only want to operate to the inquiries of tomorrow, but in addition on the thoughts in the working day following tomorrow.’

Our study ranges in the biophysics of DNA to synthetic cells and past. Make sure you have a look below on the spectrum of our existing tasks.

‘In the beginning we checked out Organic methods by using a Actual physical check out and acted on The idea of the resources we knew. It took a few years ahead of we begun Operating far more on the massive Organic problems. I then started to contact it nanobiology, a phrase that didn't exist at some time.

Finding out DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.

Let's say, instead of working with standard major-down silicon electronics, transistors may be constructed from The underside up utilizing one organic molecules as being the switching components? This concept, which turned The idea of now’s subject of molecular electronics, first emerged from the 1970s.

There was 1 difficulty even though — we did not observe any measurable electrical conduction from The only ceesdekker.net polymer molecules. We concluded that at The only-molecule degree, conducting polymers have been basically not such great conductors, which was fairly disappointing. We Hence broadened our look at to test to seek out far more promising molecules.

Case in point (four) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is proven in grey, the rim of the pore is highlighted in pink, plus a 3D rendering on the motion of the DNA rod is exhibited.

Later on we spoke again briefly due to the fact Dekker felt that our dialogue of his religion immediately became purely philosophical, whereas In addition, it concretely can help him in his do the job.

Enable’s to start with look back for the time being once you chose to shift your emphasis from superconductivity and nanotubes to biology at the end of the nineties.

Supercoiling-dependent DNA binding: quantitative modeling and apps to bulk and solitary-molecule experiments